Study Details Methods Results Conclusions
-Kirchner and Anitua, 2016
-Sample size=86
-Follow-up = 6 months
-Observational retrospective pilot study
86 patients who simultaneously underwent one intradiscal, an intra-articular facet, and a transforaminal epidural injection of PRGF under fluoroscopy
-Outcomes assessed with VAS
VAS decreased significantly at 1,3 and 6 months post-treatment. (P<0.05)

VAS showed a statistically significant drop at 1, 3, and 6 months after the treatment (P < 0.0001) except for the pain reduction between the 3rd and 6th month whose signification was lower (P < 0.05)
•Positive study
• Low-quality observational study.
• Numerous confounding factors due to multiple interventions at once.
-Wu et al, 2016
-Sample size=19
-Follow-up=3 months
-Prospective clinical evaluation
19 patients given intra-articular injections of PRP
-Outcomes were assessed with VAS, ODI, and RMDQ
• 79% of the patients reported improvement with good or excellent at 3 month follow-up post-intervention
• ODI and RMDQ were also significantly improved.
• Positive results in a study with a small number of patients
• relatively short follow-up of 3 months
-Wu et al, 2017
-Sample size=46
-Follow-up=6 months
-Prospective randomized
trial
46 patients with lumbar
facet syndrome were
randomized to intra-articular injections of PRP
versus LA/corticosteroid
Outcomes were assessed
with VAS, ODI, and
RMDQ
• Back pain improved in both groups
• At 3 months, back pain relief was superior in PRP injection group compared to steroid group
• Functional status improvement was observed in both groups; however, degree of improvement was greater for PRP than for steroid group.
• Highest improvement rate with over 50% pain relief in 81% was found at 3 and 6 months after treatment, in contrast to highest success rate in 85% of the patients in the steroid group after one month
• Positive study
• There was significant improvement in both groups in short-term. However, improvement was long lasting for 6 months in PRP group
• Limited with a small number of patients